2017 Fiscal Year Final Research Report
Regulation and physiological role of mitochondrial fusion and fission in mammals
| Project/Area Number |
26291044
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | ミトコンドリア / オルガネラ / 膜融合 / 膜分裂 / GTPase |
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| Outline of Final Research Achievements |
Mitochondrial dynamics by frequent fusion and fission have important roles in various cellular signaling processes and pathophysiology in vivo. However, the molecular mechanism that regulates mitochondrial fusion and fission in mammalian cells are not well understood. We analyzed molecular mechanism to regulate mitochondrial morphology in mammalian cells, by balanced mitochondrial fusion and fission. We also found important roles of mitochondrial fission in formation of cardiomyocytes during neonatal heart development, and maintenance of oocyte quality.
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| Free Research Field |
分子細胞生物学
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