Molecular mechanism of germline maintenance and differentiation via long-noncoding RNAs

2017 Fiscal Year Final Research Report

• Project/Area Number: 26291048
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Developmental biology
• Research Institution: Osaka University
• Principal Investigator: KAI TOSHIE 大阪大学, 生命機能研究科, 教授 (40579786)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 生殖細胞 / 非コードRNA / 発生・分化

Outline of Final Research Achievements

In this study, we analyzed the molecular function of noncoding RNAs which regulate maintenance and differentiation of germline stem cells using Drosophila as a model organism. We identified wide-variety of long noncoding RNAs expressed only in germline stem cells, and we hope to elucidate their expression network. We also clarified the dynamics of small noncoding piRNA during spermatogenesis, and the role of heterochromatic protein 1 (HP1a) in piRNA biosynthesis during the subsidy period. These results would consolidate the basis for comprehensive understanding of germline-specific noncoding RNAs.

Free Research Field

発生生物学