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2016 Fiscal Year Final Research Report

Three-dimensional structure and functionof ABC transporter responsible for macromolecule transport in bacteria

Research Project

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Project/Area Number 26292044
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Applied microbiology
Research InstitutionSetsunan University

Principal Investigator

Murata Kousaku  摂南大学, 理工学部, 教授 (90142299)

Co-Investigator(Kenkyū-buntansha) 橋本 渉  京都大学, (連合)農学研究科(研究院), 教授 (30273519)
丸山 如江  摂南大学, 理工学部, 助教 (90397563)
Project Period (FY) 2014-04-01 – 2017-03-31
KeywordsABCトランスポーター / X線結晶構造 / 基質結合タンパク質 / ABCタンパク質 / アルギン酸 / 体腔 / スフィンゴモナス属細菌
Outline of Final Research Achievements

The ABC transporter in gram negative bacterium Sphingomonas sp. A1 functions, under the cooperation with substrate-binding protein ptesent in periplasm, in the transport of macromolecules such as alginate present in milieu into cytoplasm, Through the X ray analysis, we have succeeded in the determination of the complex of ABC transporter and substrate-binding protein, and almost completely solved the molecularmechanism of the transport and its biological significans in microorganisms.

Free Research Field

応用微生物学

URL: 

Published: 2018-03-22  

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