2016 Fiscal Year Final Research Report
Functional plasticity in E. coli ribosome
| Project/Area Number |
26292048
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
Miyazaki Kentaro 国立研究開発法人産業技術総合研究所, 生物プロセス研究部門, 研究グループ長 (60344123)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | リボソーム / 16S rRNA / 中立進化 / キメラ遺伝子 / 機能相補 |
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| Outline of Final Research Achievements |
Using E. coli null mutant of run operons, we have succeeded in obtaining functional 16S rRNA genes from various bacteria, including those from Acidobacteria, Firmicutes, and Bacteroidetes phylum, that are distantly related to E. coli. The unexpected functional plasticity in the E. coli ribosome suggest that the 16S rRNA genes have evolved by accumulating lineage-specific functionally nearly neutral evolution.
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| Free Research Field |
応用微生物学
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