2016 Fiscal Year Final Research Report
Total synthesis of natural products with potent cytotoxicity and unique structures directed toward their chemical biologicl studies.
| Project/Area Number |
26292056
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bioorganic chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
清田 洋正 岡山大学, その他の研究科, 教授 (30234397)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | amphidinolide / nigricanoside / total synthesis / oxylipin / cytotoxic |
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| Outline of Final Research Achievements |
Total synthetic studies on two potent cytotoxicns, amphidinolide N and nigricanoside A) were conducted with the intention of promoting their chemical biological studies. The synthesis of the C17-C29 fragment of the former natural product was accomplished by developing an efficient one-pot THF ring-forming processs. The southeastern segment of the latter was also prepared by exploiting the Evans asymmetric alkylation as a key step. The total synthesis of two natural oxylipins, the structures of which are similar to the oxylipin units incorporated in nigricanoside A, were also achieved and provided some important information useful for the total synthesis of nigricanoside A.
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| Free Research Field |
有機合成化学
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