2017 Fiscal Year Final Research Report
Physiological functions of branched-chain amino acids as regulatory factors in mammals
| Project/Area Number |
26292068
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
北浦 靖之 名古屋大学, 生命農学研究科, 助教 (90442954)
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| Research Collaborator |
KADOTA Yoshihiro
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 分岐鎖アミノ酸 / 分岐鎖αケト酸脱水素酵素キナーゼ / 分岐鎖アミノ酸分解亢進 / コンディショナルノックアウト / マウス / 筋肉 / 脂肪組織 / 運動 |
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| Outline of Final Research Achievements |
Branched-chain amino acids (BCAA) are essential amino acids in mammals. The aims of the present study were to elucidate the importance of branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex as the rate-limiting enzyme in the BCAA catabolism in vivo and diverse functions of BCAA as important factors to regulate systemic metabolism using global and conditional BCKDH kinase-knockout (BDK-KO) mice. In both global and muscle specific BDK-KO mice, plasma and muscle BCAA concentrations were significantly decreased, indicating that BCKDH complex is an important enzyme to regulate the BCAA catabolism. Furthermore, in the studies using these mice, it was suggested that BCAA play important roles in regulation of muscle protein metabolism, endurance exercise performance, and energy metabolism.
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| Free Research Field |
農学
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