Exploration of mechanism underlying differentiation to brown/brite adipocytes in fat depots of fattening cattle

2016 Fiscal Year Final Research Report

• Project/Area Number: 26292137
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Animal production science
• Research Institution: Kyoto University
• Principal Investigator: Matsui Tohru 京都大学, (連合)農学研究科(研究院), 教授 (40181680)
• Co-Investigator(Kenkyū-buntansha): 友永 省三 京都大学, (連合)農学研究科(研究院), 助教 (00552324)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 褐色脂肪細胞 / Brite細胞 / ウシ / ビタミンA

Outline of Final Research Achievements

We established culture condition to differentiate stromal-vascular cells originated from bovine adipose tissues to brite (brown in white) adipocytes. Retinoic acid had an inhibitory effect on expression of Ucp1, a gene predominantly expressed in brite adipocytes. Feeding vitamin A-restricted diet did not affect expression level in adipose tissues of Japanese Black fattening cattle. However, Ucp1 expression was slightly higher in brite adipocytes differentiated from stromal vascular cells isolated from vitamin A-restricted cattle than in those from control cattle.

Free Research Field

家畜栄養学