Construction of new functional yogurt with prevention to IBD(inflamatory bowel disease) by blood type lactic acid bacteria.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26292143
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Animal production science
• Research Institution: Tohoku University
• Principal Investigator: SAITO TADAO 東北大学, (連合)農学研究科(研究院), 教授 (00118358)
• Co-Investigator(Kenkyū-buntansha): 北澤 春樹 東北大学, (連合)農学研究科(研究院), 准教授 (10204885)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ビフィズス菌 / 乳酸菌 / 潰瘍性大腸炎 / 炎症性腸疾患 / 血液型乳酸菌 / 機能性ヨーグルト

Outline of Final Research Achievements

Inflammatory bowel diseases such as ulcerative colitis or Crohn disease increase rapidly in the young Japanese recently. The cause is still unknown and becomes the big problem in the world. We studied the yogurt using the lactic acid bacteria (LAB) which remove harmful bacteria by production of antibacterial peptides or stimulate immunity until now. We studied
the adhesion of bacteria to human intestine by a biosensor Biacore and discovered "a blood type lactic acid bacterium" in human intestinal tract for the first time in the world. Using a blood type lactic acid bacterium indicating this high human intestinal tract adhesion, we could developed the new feature-related yogurt which enabled the prevention and remission by removing a pathogen and various harm bacteria of the ulcerative colitis by the competitive inhibition according to the blood type and, in this study, showed possibility to prevent illness.

Free Research Field

応用微生物学