Involvement of nociceptive channels as molecular basis of neuropathic pain development

2017 Fiscal Year Final Research Report

• Project/Area Number: 26292150
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Veterinary medical science
• Research Institution: Tottori University
• Principal Investigator: Ohta Toshio 鳥取大学, 農学部, 教授 (20176895)
• Co-Investigator(Kenkyū-buntansha): 高橋 賢次 鳥取大学, 農学部, 准教授 (00400143)
• Co-Investigator(Renkei-kenkyūsha): IMAGAWA Toshiaki 北海道大学, 理学研究科, 准教授 (20142177)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 疼痛

Outline of Final Research Achievements

This study was performed to clarify regulatory mechanisms of endogenous substances and analgesic effect on TRPA1, which is mainly expressed in sensory nerves as a molecular basis of nociceptors with highly reactive to ambient temperature and irritating chemical substances. TRPA1 was activated by sulfur-containing compounds and carbonyl stress-induced products in vivo, causing a pain response. It was also found that one of the plant-derived terpenoids has an analgesic effect via the suppression of TRPA1 channel. In addition, a single amino acid was identified for the site of action of a blocking agent with a high potency against mammalian homologues by molecular biological approach utilizing species differences. These studies revealed the pathophysiological significance of the relationship between nociceptive channel and pain.

Free Research Field

神経薬理学