2016 Fiscal Year Final Research Report
Comprehensive analysis of molecular mechanisms of drug resistance in canine malignant tumors
Project/Area Number |
26292158
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Veterinary medical science
|
Research Institution | The University of Tokyo |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
渡邊 学 東京大学, 新領域創成科学研究科, 准教授 (70376606)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Keywords | 犬 / 悪性腫瘍 / 薬剤耐性 / 網羅的解析 |
Outline of Final Research Achievements |
Drug resistance is a major cause of the failure in the chemotherapy for malignant tumors in dogs. In this study, comprehensive analysis of gene expression profiles revealed that immune responses and inflammatory reactions were suppressed in lymphoma tissues at the acquisition of drug resistance. In addition, a model to predict chemotherapy resistance was established using expression profiles of 6 genes associated with immune/inflammatory responses. This study revealed novel mechanisms of chemotherapy resistance and suggested that the resistance to chemotherapy could be predicted by the quantification of the 6 genes before chemotherapy. Findings obtained from this study would be beneficial for the chemotherapy in dogs and also provide useful information for the cancer chemotherapy in humans.
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Free Research Field |
農学
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