2016 Fiscal Year Final Research Report
Development of Boronated Cholesterols and their Highly Functionalized Nano Carriers for New Generation Neutron Capture Therapy
| Project/Area Number |
26293007
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
布施 新一郎 東京工業大学, 資源化学研究所, 准教授 (00505844)
佐藤 伸一 東京工業大学, 資源化学研究所, 助教 (20633134)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | がん治療 / イメージング / 中性子捕捉療法 / リポソーム / 生体分子 / 放射線 / 蛍光 |
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| Outline of Final Research Achievements |
Boronated cholesterols were successfully synthesized. Using these cholesterol, high content boron liposomes were developed for new generation neutron capture therapy. A counter cation of boron ion clusters (closo-dodecaborates) was found to be essential for the encapsulation efficacy of boronated liposomes: a sperimidinium form of closo-dodecaborates was highly encapsulated into liposomes prepared from phospholipids. Furthermore, boron imaging technologies in the cells have been developed using a combination of in cell click fluorescent imaging technique and Raman imaging technology.
Biopolymer-based boron delivery system was also developed for selective and efficient delivery of boron to tumor in vivo based on the EPR effect. Maleimide-closo-dodecaborate (MID) was successfully synthesized. MID conjugated not only a free SH group of cysteine residues but also lysine residues in proteins and its serum albumin conjugates were found to be accumulated into tumor selectively.
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| Free Research Field |
有機化学
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