Biological activities and drug development of natural compounds with bone-resorbing and bone-forming properties during bone metabolism

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293024
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Natural medicines
• Research Institution: Chubu University
• Principal Investigator: WOO Je-Tae 中部大学, 応用生物学部, 教授 (20272693)
• Co-Investigator(Kenkyū-buntansha): 大西 素子 中部大学, 応用生物学部, 教授 (00312653) ; 車 炳允 中部大学, 生物機能開発研究所, 准教授 (00410663) ; 中川 大 中部大学, 応用生物学部, 講師 (40397039) ; 林 宣宏 東京工業大学, 生命理工学研究科, 准教授 (80267955)
• Co-Investigator(Renkei-kenkyūsha): TEI Yuichi 東京大学, 大学院工学系研究科, 教授 (30345053) ; OTA Masato 日本女子大学, 家政学部, 准教授 (70313228)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 骨代謝 / 骨吸収抑制剤 / 骨形成促進剤 / 天然化合物

Outline of Final Research Achievements

To elucidate the effect and mechanism of natural compounds which have both anti-resorptive action and anabolic action in bone metabolism, the following studies in vitro and in vivo were performed. It is demonstrated that honokiol might promote osteoblast differentiation throgh retinoid X receptor and sonic hedgehog pathway. The in vivo study revealed that honokiol suppresses bone loss in ovariectomized and RANKL-treated osteoporosis model mice. We also found that Nitensidine A from Pterogynine Nitens and Epimagnolin A from Magnolia Flower interact with ABCB1.

Free Research Field

天然物化学