Circadian transcriptome analysis for protection against obesity development

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293048
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Koike Nobuya 京都府立医科大学, 医学(系)研究科(研究院), 講師 (00399685)
• Research Collaborator: Chen Zheng The University of Texas Health Science Center at Houston, Department of Biochemistry & Molecular Biology, Associate Professor
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 概日リズム / トランスクリプトーム / メタボリズム / 時計遺伝子

Outline of Final Research Achievements

In mammals, the circadian clock is cell autonomous and comprised of an autoregulatory transcriptional and translational feedback loop composed of several clock genes and their protein products. A growing body of evidence revealed a close link between the circadian clock and metabolism. In this study, using a mouse model of diet-induced obesity, we revealed that enhancement of circadian clock oscillation renders protection against metabolic syndrome. Daily restricted feeding caused disturbance of circadian transcriptional networks in a tissue specific manner. The genes involved in lipid metabolism were enriched in the differentially expressed genes between daytime and nighttime food restriction, suggesting that they may contribute to obesity.

Free Research Field

時間生物学、分子生物学