2016 Fiscal Year Final Research Report
Roles of the PrRP-oxytocin system in the control of stress and social behavior
| Project/Area Number |
26293049
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Research Collaborator |
TAKAYAHAGI Yuki
YOSHID Masahide
INUTSUKA Ayumu
OKABE Shota
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | PrRP / オキシトシン / ストレス |
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| Outline of Final Research Achievements |
I have previously shown that the medullary prolactin releasing peptide (PrRP)-producing neuron-hypothalamic oxytocin-producing neuron system is activated by food intake and that activation of the PrRP-oxytocin system terminates food intake. In the preset study, I investigated physiological roles of the PrRP-oxytocin system in the control of conditioned fear or social stress-related responses. The PrRP-oxytocin system was activated following conditioned fear and social defeat stimuli. PrRP deficiency facilitated freezing behavior during conditioned fear stimuli, suggesting inhibitory roles of PrRP in conditioned fear-induced freezing behavior. On the other hand, oxytocin receptor deficiency attenuated defeat posture during social defeat stress, suggesting facilitative roles of oxytocin in the social defeat posture. All these data are consistent with a view that the PrRP-oxytocin system plays different roles in the control of stress responses dependent upon stressful stimuli used.
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| Free Research Field |
行動神経内分泌
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