The origin of endogenous pluripotent Muse cells and their role in tissue homeostasis

2017 Fiscal Year Final Research Report

• Project/Area Number: 26293058
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Tohoku University
• Principal Investigator: Dezawa Mari 東北大学, 医学系研究科, 教授 (50272323)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 再生医学 / 多能性幹細胞 / 間葉系幹細胞

Outline of Final Research Achievements

Mammalian Muse cells are endogenous pluripotent stem cells. On the other hand, planarians who have high regenerative capacity also hold endogenous pluripotent stem cells called neoblast in the connective tissue. Focusing on this similarity, we explored distribution, mobility and functionality of Muse cells in vivo. Muse cells distributed in the bone marrow, peripheral blood and, similar to planarians, the connective tissue of nearly every organ. Muse cells were mobilized from the bone marrow to the peripheral blood in response to S1P signal produced by damaged tissue, preferentially migrated to and homed into the damaged site, and repair the tissue by spontaneous differentiation into tissue-compatible cells. Thus, they are contributing to daily tissue homeostasis as well as to reparative function after tissue damage.

Free Research Field

医歯薬学　再生医学