2017 Fiscal Year Final Research Report
Regulation of axon regeneration in C. elegans
| Project/Area Number |
26293063
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | C. elegans / 細胞内シグナル伝達 / 軸索再生 |
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| Outline of Final Research Achievements |
In a nematode Caenorhabditis elegans, initiation of axon regeneration in injured neuron is positively regulated by SVH-1, which activates a JNK MAP kinase cascade via a c-Met-like receptor tyrosine kinase SVH-2. In this study, we demonstrated that SVH-4, a receptor tyrosine kinase that is activated by collagen, acts upstream of the SVH-2-JNK pathway. We also found that SVH-1 controls larval growth via an extracellular matrix component FBL-1. Furthermore, we showed that HIF-1-mediated activation of 5-HT signaling promotes axon regeneration by activating both the RhoA and cAMP pathways.
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| Free Research Field |
分子生物学
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