Involvement of Cxcl12/Cxcr4 signaling deficits in schizophrenia

2017 Fiscal Year Final Research Report

• Project/Area Number: 26293074
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Research Institute, Shiga Medical Center
• Principal Investigator: Tanigaki Kenji 滋賀県立成人病センター(研究所), 神経病態研究部門, 専門研究員 (70362473)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 統合失調症 / Cxcr4 / Cxcl12 / ケモカイン

Outline of Final Research Achievements

22q11 deletion syndrome is a chromosome disorder. 20-30% of the patients with this deletion develop schizophrenia. We previously showed that the heterozygous deletion of Dgcr8 caused Cxcl12/Cxcr4 signaling deficits, leading to developmental abnormalities in the dentate gyrus of the hippocampus and interneruons. In this study, we examined whether Cxcl12/Cxcr4 signal deficits can cause schizophrenia-like behavioral abnormalities using Cxcr4-floxed mice, and whether Cxcl12/Cxcr4 signal deficits exist in sporadic schizophrenia patients using lymphodblastic cell lines.

Free Research Field

神経科学、精神医学