Evaluation of the risk of infectious/immunity-related diseases conferred by genetic polymorphisms in the HLA system

2017 Fiscal Year Final Research Report

• Project/Area Number: 26293076
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Human genetics
• Research Institution: 地方独立行政法人佐賀県医療センター好生館(ライフサイエンス研究所) (2016-2017); Nagasaki University (2014-2015)
• Principal Investigator: YASUNAMI Michio 地方独立行政法人佐賀県医療センター好生館(ライフサイエンス研究所), ライフサイエンス研究所, 部長 (80244127)
• Co-Investigator(Kenkyū-buntansha): 右田 清志 福島県立医科大学, 医学部, 教授 (60264214)
• Co-Investigator(Renkei-kenkyūsha): ARIYOSHI Koya 長崎大学, 熱帯医学研究所, 教授 (30311400) ; HIRAI Hirohisa 京都大学, 霊長類研究所, 教授 (10128308) ; KAWAI Satoru 獨協医科大学, 医学部, 准教授 (70275733)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: ゲノム / 疾患リスク / 表現型分析 / 感染症 / 免疫異常

Outline of Final Research Achievements

HLA is composed of highly polymorphic molecules mainly due to variations in the regions involved in specificity determination during antigen presentation processes. Thus the HLA polymorphism leads to heterogeniety in immune response between individuals. In this study, we revealed an inhibitory effect of certain HLA class II alleles in several different infectious/immunity-related diseases. These results suggested the presence of additional underlying common regulatory mechanism(s) in immunity/inflammation via HLA class II molecules.

Free Research Field

人類遺伝学