Molecular mechanism of relapse and transformation of follicular lymphoma

2017 Fiscal Year Final Research Report

• Project/Area Number: 26293078
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Okayama University
• Principal Investigator: Yoshino Tadashi 岡山大学, 医歯薬学総合研究科, 教授 (70183704)
• Co-Investigator(Kenkyū-buntansha): 竹内 真衣 岡山大学, 医歯薬学総合研究科, 助教 (10759666) ; 高田 尚良 岡山大学, 医歯(薬)学総合研究科, 講師 (90580259)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: リンパ腫 / 濾胞性リンパ腫 / がん幹細胞 / 形質転換

Outline of Final Research Achievements

Follicular lymphoma is one of the most frequent lymmphoma, and it has increased in number of patients: approximately 6000 new patients a year and it is almost 20% of all lymphoma. Although this lymphoma is quite indolent clinical course, it recurres so freqently, and high-grade transformation is the serious problem to control. We revealed that cancer initiating cells are present in this lymphoma which is closely associated with high frequent recurrence, and examined the role of c-MYC and BCL2 translocation at the course of high-grade transformation.

Free Research Field

病理学