2016 Fiscal Year Final Research Report
Establishing the molecular pathology-based subclassification of hepatocellular carcinoma.
| Project/Area Number |
26293081
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Keio University |
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Principal Investigator |
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| Research Collaborator |
FUKUMA Mariko
YAMAZAKI Ken
EFFENDI Kathryn
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 病理学 / 肝細胞癌 / シグナル伝達 / サブクラス |
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| Outline of Final Research Achievements |
By analyzing cell signaling features and phenotype immunohistochemically, a new subclassification of hepatocellular carcinoma (HCC) that reflects the degree of malignancy was established. Activated MAPK signaling or overexpression of Glypican 3 as therapeutic target candidates were shown in biliary/stem cell marker-positive HCCs. The use of MRI to diagnose HCC with activated WNT signaling was also revealed. These findings are expected to be applied in the clinical practice.
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| Free Research Field |
分子病理学、肝臓病理学、細胞生物学（浸潤・転移）
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