2016 Fiscal Year Final Research Report
Regulation of tissue injury by inflammotion-regulating Macrophages
| Project/Area Number |
26293089
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
Tanaka Masato 東京薬科大学, 生命科学部, 教授 (00294059)
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| Co-Investigator(Kenkyū-buntansha) |
大村谷 昌樹 熊本大学, 学内共同利用施設等, 准教授 (60398229)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 炎症 / マクロファージ / 虚血再灌流傷害 |
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| Outline of Final Research Achievements |
In this study, we tried to reveal the mechanisms of immune regulation by CD169-positive macrophages. We analyze the localization and character of these CD169-positive macrophages in various tissues using CD169-Cre-YFP mice. We also examined the pathological roles of these macrophages in ischemic-reperfusion injury of kidney and DSS-induced colitis. In addition, we identified a CD169-positive macrophage-specific transcription factor. We found that this transcription factor not only promotes CCL8 production, but also suppresses gene expression related to anti-inflammation or tissue repair in these macrophages.
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| Free Research Field |
医歯薬学
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