2016 Fiscal Year Final Research Report
| Project/Area Number |
26293094
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Chiba University |
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Principal Investigator |
Saijo Shinobu 千葉大学, 真菌医学研究センター, 准教授 (60396877)
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| Co-Investigator(Kenkyū-buntansha) |
岩倉 洋一郎 東京理科大学, 付置研究所, 教授 (10089120)
米山 光俊 千葉大学, 真菌医学研究センター, 教授 (40260335)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | C-type lectin / 遺伝子改変動物 / サイトカイン |
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| Outline of Final Research Achievements |
Myeloid cells act central roles in inflammatory responses. C-type lectin receptors (CLRs) are key players that are expressed mainly in these cells to orchestrate immune responses for maintaining immune homeostasis. These receptors recognize carbohydrate structures in microbes, including fungi, bacteria, viruses, and parasites, as pathogen-associated molecular patterns (PAMPs). Owing to the activities, the pleiotropic roles of CLRs has been suggested to have an important effect on homeostasis in the body. In this study, we found that collaboration of several C-type lectins are important in anti-fungal immunity.
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| Free Research Field |
実験動物学
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