The molecular basis for persistent inflammation in Helicobacter pylori-infected gastric mucosa and their application to a novel vaccine

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293095
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Bacteriology (including mycology)
• Research Institution: The University of Tokyo
• Principal Investigator: Mimuro Hitomi 東京大学, 医科学研究所, 准教授 (80396887)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 持続感染 / 病原体

Outline of Final Research Achievements

In this study we performed the following studies, to develop a more comprehends understanding of mechanisms underlying persistent inflammation in Helicobacter pylori-infected gastric mucosa, and to try to apply the outcome to vaccine development. (1) Control mechanisms of gastric responses: we have discovered a novel mechanism to regulate adherence function of bacterial adhesin BabA during persistent infection. (2) Control mechanisms of intestinal Peyer’s patches: we comprehensively analyzed outer membrane protein profiles of H. pylori under anaerobic conditions, and identified candidate factors for the interaction of bacteria with antigen presenting cells. (3) Vaccine: we analyzed prophylactic vaccine effect of anaerobic cultured bacteria for H. pylori infection using a Mongolian gerbil animal model of H. pylori infection.

Free Research Field

細菌学