Clarification of the intestinal immune regulatory mechanisms by dendritic cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293106
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Immunology
• Research Institution: Wakayama Medical University
• Principal Investigator: Tsuneyasu Kaisho 和歌山県立医科大学, 先端医学研究所, 教授 (60224325)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 樹状細胞 / 腸管免疫 / ケモカイン / 免疫応答 / T細胞 / 遺伝子改変マウス

Outline of Final Research Achievements

We have generated the mutant mice lacking a dendritic cell subset expressing a chemokine receptor, XCR1, (XCR1+DC) constitutively and have found that XCR1+DC was required for keeping intestinal immune homeostasis. This indicates novel XCR1+DC-dependent mechanisms for intestinal immune regulation. We have also generated the mutant mice expressing a fluorescence protein, Kikume, in XCR1+DC. By analyzing the mice, we have achieved in visualizing functional behavior and interaction of XCR1+DC with T cells.

Free Research Field

免疫学