A nested case-control study in the JACC Study to investigate biomarkers of premature death

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293138
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Hokkaido University
• Principal Investigator: Tamakoshi Akiko 北海道大学, 医学(系)研究科(研究院), 教授 (90236737)
• Co-Investigator(Kenkyū-buntansha): 渡辺 能行 京都府立医科大学, 医学(系)研究科(研究院), 教授 (00191809) ; 磯 博康 大阪大学, 医学(系)研究科(研究院), 教授 (50223053) ; 鈴木 康司 藤田保健衛生大学, 保健学研究科, 准教授 (60288470) ; 藤野 善久 産業医科大学, 医学部, 准教授 (80352326) ; 山田 宏哉 藤田保健衛生大学, 医学部, 助教 (80610352) ; 若井 建志 名古屋大学, 医学(系)研究科(研究院), 教授 (50270989)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: miRNA / ケースコホート研究 / 早世マーカー

Outline of Final Research Achievements

Using serum stored from the JACC Study, we measured levels of miRNA (miR-21, miR-29a and miR-216), Vitamin E, retinol and high-sensitivity C-reactive protein (hs-CRP) and compared 336 cases of death before 65 years old with 926 sub-cohort members randomly selected from those aged 40-64 years at baseline. Compared with those in the highest quartile, those whose miR-29a and hsCRP levels were in the lowest quartile had a significantly lower risk of premature death. A similar tendency was also found for miR-126 levels. However, it was not statistically significant. Other biomarkers shoed no meaningful associations. We will interpret the results carefully to ascertain the significance of these biomarkers.

Free Research Field

疫学