2016 Fiscal Year Final Research Report
Identification of mechanisms of immediate death after blunt force impact to the head
| Project/Area Number |
26293164
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 外傷性脳損傷 / 頭部外傷 |
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| Outline of Final Research Achievements |
Patients with brain injury may die immediately after receiving the impact to the head. Forensic diagnosis of cause of death in such patients is difficult, because edema and herniation may not have developed in the brain due to short survival period of time. This study was performed to identify the mechanisms of immediate death after head trauma. Experimental studies using animal models and analyses of autopsy cases revealed that blunt force impact to the parietal region of the head relates to the cardio-pulmonary arrest and immediate death after the impact. In addition, experimental studies using animal models identified neuronal degeneration in the brain stem after receiving impact to the head and suggested that senescent cells relate to the mechanisms of progression of traumatic brain injury.
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| Free Research Field |
法医学
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