Anti-cancer therapies baesd on novel cancer stem cell-specific factors

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293173
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kyoto University
• Principal Investigator: Seno Hiroshi 京都大学, 医学(系)研究科(研究院), 教授 (90335266)
• Co-Investigator(Renkei-kenkyūsha): FUKUDA Akihisa 京都大学, 大学院医学研究科, 助教 (70644897)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 癌 / 幹細胞

Outline of Final Research Achievements

In this study, we explored the nature of cancer stem cells, and sought the possibility of anti-cancer stem cell-targeting therapies. For that purpose, we performed the experiments as follows. 1) In the intestine, transcriptome of cancer stem cells was analyzed based on the expression of various stem cell markers, especially Dclk1. 2) The roles of Dclk1 and novel cancer stem cell-specific markers were investigated in mouse gastric, pancreatic, and gall bladder cancer models. 3) Therapeutic potentials of kinases and cell surface proteins in cancer stem cells were examined in mouse cancer models and cancer spheroids. Based on these experiments, basis for the development of anti-cancer stem cell therapies was established.

Free Research Field

消化器内科学