Role of the novel adipocytokine in regulation of cardiovascular disease

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293185
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Nagoya University
• Principal Investigator: Ouchi Noriyuki 名古屋大学, 医学(系)研究科(研究院), 寄附講座教授 (00595514)
• Co-Investigator(Kenkyū-buntansha): 大橋 浩二 名古屋大学, 医学(系)研究科(研究院), 寄附講座助教 (10595515) ; 柴田 玲 名古屋大学, 医学(系)研究科(研究院), 寄附講座准教授 (70343689) ; 室原 豊明 名古屋大学, 医学(系)研究科(研究院), 教授 (90299503)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 分子心臓病態学 / 虚血性心疾患

Outline of Final Research Achievements

Here we investigated the role of the novel adipokine adipolin in regulation of cardiovascular disease. We found that adipolin knockout mice had increased myocardial infarct size and reduced cardiac function following ischemia-reperfusion compared with control mice, which were accompanied by enhanced inflammatory response in ischemic heart. Furthermore, adipolin reduced inflammatory responses in cultured cardiac myocytes and macrophages, and attenuated endothelial cell apoptosis. Thus, adipolin can serve as a cardiovascular protective adipocytokine.

Free Research Field

医歯薬学