Cooperative regulation of cardiac function by insulin and IGF

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293194
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kansai Medical University
• Principal Investigator: Shiojima Ichiro 関西医科大学, 医学部, 教授 (90376377)
• Co-Investigator(Renkei-kenkyūsha): IWASAKI Masayoshi 関西医科大学, 医学部, 講師 (30548706)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 心機能 / インスリン / IGF

Outline of Final Research Achievements

Insulin/Insulin-like growth factor (IGF) signaling regulates multiple cellular processes including glucose homeostasis and cell growth/proliferation. To investigate the role of insulin and IGF signaling in the regulation of contractile function, insulin receptor (IR) or IGF receptor (IGFR) was deleted in cardiac muscle cells either alone or in combination. Although contractile function was not affected by cardiac-specific IR deletion or IGFR deletion, simultaneous deletion of IR/IGFR in the heart resulted in a marked decline in contractility associated with left ventricular dilatation. Our results suggest the cooperative and redundant roles of cardiac insulin/IGF signaling in the regulation of contractile function.

Free Research Field

循環器内科学