Clarification of pathogenesis in chronic obstructive pulmonary disease focusing on lung resident cells.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293195
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Tohoku University
• Principal Investigator: Sugiura Hisatoshi 東北大学, 医学(系)研究科(研究院), 准教授 (20445092)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 酸化型コレステロール / 細胞老化 / 転写因子 / KLF5 / 活性硫黄分子種 / 成長因子

Outline of Final Research Achievements

We demonstrated the followings. Production of 27-OHC was enhanced in the patients with COPD. Treatment with 27-OHC accelerated cellular senescence of lung resident cells and chronic exposure of 27-OHC impaired fibroblast-mediated tissue repair function. Bronchial fibroblasts from COPD patients showed marked pro-fibrotic feature compared to those from control subjects. KLF-5 regulated the profibrotic effects in the cells and expression of KLF-5 was enhanced in the peribronchial lesion of small airways of COPD patients. We demonstrated that production of newly identified anti-oxidants, reactive persulfides species was reduced in the lungs of COPD patients compared with healthy controls. We found that the plasma levels of GDF11, which is an anti-senescent factor, were decreased in COPD patients compared with healthy subjects.

Free Research Field

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