Double-face culture system for application of alveolar epithelial cells induced from human iPS cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293199
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Kyoto University
• Principal Investigator: Isao Ito 京都大学, 医学(系)研究科(研究院), 助教 (40447975)
• Co-Investigator(Kenkyū-buntansha): 半田 知宏 京都大学, 医学(系)研究科(研究院), 助教 (10432395) ; 小寺 秀俊 京都大学, 工学(系)研究科(研究院), 教授 (20252471) ; 平井 豊博 京都大学, 医学(系)研究科(研究院), 准教授 (20359805) ; 劉 莉 京都大学, 学内共同利用施設等, 助教 (50380093) ; 三嶋 理晃 京都大学, 医学(系)研究科(研究院), 教授 (60190625) ; 室 繁郎 京都大学, 医学(系)研究科(研究院), 講師 (60344454) ; 新宅 博文 京都大学, 工学(系)研究科(研究院), 助教 (80448050) ; 長船 健二 京都大学, 学内共同利用施設等, 教授 (80502947)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: iPS細胞 / 肺胞上皮細胞 / 気道上皮細胞 / 肺前駆細胞 / ナノファイバー

Outline of Final Research Achievements

There are many kinds of difficult-to-treat respiratory diseases. In such cases, many patients die from respiratory failure. For most of the respiratory diseases, no curable treatment has been developed so far, and researches of the diseases have not reached the pathogenesis. If we could develop lung epithelial cells from human iPS cells and utilize the developed cells for researches and regenerative medicine, medicine in this field would largely progress. As such, we developed lung epithelial cells from human iPS cells and further tried to enhance the technique by merging with engineering technology such as nanofibers in this research program. It became possible to develop alveolar epithelial cells from iPS cells in three-dimension and to develop bronchial epithelial cells in two-dimension.

Free Research Field

iPS細胞