2016 Fiscal Year Final Research Report
Inorganic phosphate balance in cerebrospinal fluid and hyperphosphatemia
| Project/Area Number |
26293204
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
瀬川 博子 徳島大学, 大学院医歯薬学研究部, 講師 (70325257)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 唾液 / 腎臓 / リン / 慢性腎臓病 / トランスポーター |
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| Outline of Final Research Achievements |
Cerebrospinal fluid (CSF) inorganic phosphate (Pi) may regulate a central NaPi transporter expression and transduce signals to initiate the appetitive behavior and saliva Pi adaptations. However, the regulation of salivary Pi concentration remains unknown. In the salivary gland duct cell, Npt2b is localized and regulates the concentration of salivary Pi concentrations. Salivary Pi levels are controlled by dietary phosphorus contents and Npt2b is undergoing rapid regulation. In addition, in the chronic kidney disease (CKD) model, salivary Pi concentrations were significantly increased in Npt2b (-/+) mice compared with those in Npt2b (+/+) mice. In conclusion, Npt2b in the salivary glands may be important molecule for Pi homeostasis as well as Npt2a in the kidney.
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| Free Research Field |
内科臨床医学・腎臓内科学
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