Roles of Pin1 and PAR 14 on the metabolic regulations

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293219
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Hiroshima University
• Principal Investigator: Asano Tomoichiro 広島大学, その他の研究科, 教授 (70242063)
• Co-Investigator(Kenkyū-buntansha): 中津 祐介 広島大学, 医歯薬保健学研究院(医), 助教 (20452584) ; 福嶋 俊明 広島大学, 医歯薬保健学研究院, 助教 (70543552)
• Co-Investigator(Renkei-kenkyūsha): SAKODA HIDEYUKI 東京大学, 附属病院, 助教 (50376464) ; FUJISHIRO MIDORI 東京大学, 附属病院, 助教 (50420211) ; HONDA HIROAKI 広島大学, 原爆放射線医科学研究所, 教授 (40245064)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 代謝 / 糖尿病 / Pin1 / インスリン / プロリン異性化酵素 / メタボリックシンドローム

Outline of Final Research Achievements

Prolyl isomerases are divided into three groups, the FKBP family, Cyclophilin and the Parvulin family (Pin1 and Par14). Pin1 is a unique prolyl isomerase binding to the motif including pSer/pThr-Pro that is phosphorylated by kinases. We have newly demonstrated Pin1 to be involved in regulating glucose and lipid metabolism. Interestingly, while Pin1 expression is markedly increased by high-fat diet feeding, Pin1 KO mice are resistant to diet-induced obesity, non-alcoholic steatohepatitis (NASH) and diabetic vascular dysfunction. These phenomena result from the binding of Pin1 to several key factors regulating metabolic functions, which include insulin receptor substrate-1, AMPK, Crtc2 and NF-kappaB p65.

Free Research Field

代謝学