2016 Fiscal Year Final Research Report
Alteration of cellular status in diabetes and autophagy
| Project/Area Number |
26293220
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Metabolomics
|
|---|
| Research Institution | Juntendo University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
藤谷 与士夫 順天堂大学, 医学(系)研究科(研究院), 准教授 (30433783)
三田 智也 順天堂大学, 医学部, 助教 (90532557)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | オートファジー / 膵β細胞 / 動脈硬化 |
|---|
| Outline of Final Research Achievements |
In this study, we investigate how autophagy failure modify the pathophysiology observed in diabetic state. We revealed that in pancreatic beta cells, the activation of autophagy weakens the toxicity induced by human IAPP. In addition, while model mice of atherosclerosis forms atheroma in artery, however, the morphology of the atherosclerotic lesions are quite different from those in human, we found that crossing with smooth muscle cell specific autophagy failure mode, model mice of atherosclerosis showed the similar morphology in the lesion to human atherosclerosis. These results suggest that autophagy failure plays critical role in the formation of human diseases.
|
| Free Research Field |
代謝学
|
