Investigation of regulatory mechanism of secretary protein kinase and its application for treatment of rheumatoid arthritis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293233
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Collagenous pathology/Allergology
• Research Institution: Keio University
• Principal Investigator: Takeuchi Tsutomu 慶應義塾大学, 医学部, 教授 (50179610)
• Co-Investigator(Kenkyū-buntansha): 中川 種昭 慶應義塾大学, 医学部, 教授 (00227745) ; 仲 哲治 国立研究開発法人医薬基盤・健康・栄養研究所, その他部局等, その他 (30303936) ; 鈴木 勝也 慶應義塾大学, 医学部, 講師 (70306695)
• Research Collaborator: TAKESHITA Masaru 慶應義塾大学, 医学部リウマチ内科, 特任助教 (10571135)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 関節リウマチ / FAM20A / キナーゼ

Outline of Final Research Achievements

We have identified FAM20A which regulates post-transcriptional protein modification as a molecule associated with pathophysiology of rheumatoid arthritis in the previous research using peripheral blood. In this research, we generated anti-FAM20A antibody and deeply analyzed association between FAM20A and affected sites. Our investigation successfully revealed the expression affected site and its induction by inflammatory cytokines. These findings suggested that post-transcriptional protein modification involved in pathophysiology of rheumatoid arthritis.

Free Research Field

リウマチ・膠原病学