2016 Fiscal Year Final Research Report
New tissue-repair and immuno-regulatory therapy with umbilical cord-derived mesenchymal stromal cells
| Project/Area Number |
26293251
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
竹谷 健 島根大学, 医学部, 講師 (30359880)
竹谷 英之 東京大学, 医科学研究所, 講師 (90206996)
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| Co-Investigator(Renkei-kenkyūsha) |
HIROSE Jun 東京大学医科学研究所附属病院, 関節外科, 特任助教 (00456112)
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| Research Collaborator |
MUKAI Takeo
MORI Yuka
Hori Akiko
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 臍帯 / 間葉系細胞 / 新生児脳性麻痺 / 新生児慢性肺疾患 / 血友病B / 再生医療 / 免疫療法 / 新生児 |
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| Outline of Final Research Achievements |
This study aimed at making disease specific model mice treated with umbilical cord-derived mesenchymal stromal cells (UC-MSC). As the model of neonatal encephalopathy, we made mice with intraventricular hemorrhage and found the UC-MSC ameliorated the neuromuscular functions and protect the reactive gliosis. We also made the newborn chronic lung disease induced by hyperoxygen, and the UC-MSC also improved the overall survival with decrease of inflammatory cytokines and interstitial fibrosis. Hemophilia B mice were induced hepatic disorder by CCl4 and UC-MSC could migrate to the injured tissue, but failed to ameliorate the damage and survival at the presence. Conclusively, UC-MSC may be useful for neonatal complications such as neuropathy and lung disease.
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| Free Research Field |
再生 血液内科
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