2016 Fiscal Year Final Research Report
Stem cell therapy for brain injuries of infants with fetal growth restriction
| Project/Area Number |
26293252
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
佐藤 義朗 名古屋大学, 医学部附属病院, 講師 (30435862)
奥村 彰久 愛知医科大学, 医学部, 教授 (60303624)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 胎児発育不全 / SGAモデルラット / 細胞療法 / 中枢神経障害 |
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| Outline of Final Research Achievements |
Fetal growth retardation is the cause of small-for-gestational age (SGA) and is a high-risk group of neurological post-injury. Various therapeutic interventions have been done to prevent post-neurological impairment, but none of them have been effective. In this study, SGA rats were inferior in early behavioral evaluation of neonates, and immune-histological analysis showed that nerve cells decreased. Intravenous administration of umbilical cord blood after birth improved behavior early in the neonatal period and also significantly increased neuronal cells immunologically. This suggested the possibility of novel therapy for neurological development of children with SGA.
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| Free Research Field |
胎児新生児学
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