2017 Fiscal Year Final Research Report
Induction of aoutoantibodies to BP230 and analysis of new function of BP230 using gene-engineered mouse
| Project/Area Number |
26293254
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松崎 康司 弘前大学, 医学部附属病院, 講師 (50322946)
中野 創 弘前大学, 医学研究科, 准教授 (90281922)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 遺伝子 / 自己免疫 / 皮膚 / 水疱 |
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| Outline of Final Research Achievements |
Bullous pemphigoid is a skin disease which shows generalized blisters and occurs mostly in the elderly. This disease is characterized by autoantibodies to basement membrane zone and considered as autoimmune blistering disease. In this study, we generated knockout mouse of BP230 and also conditional knockout mouse without epidermal BP230 expression. The results demonstrated that BP230 plays an important role in muscle function. Furthermore, BP230 has great contributions to stability of biding between the epidermis and the dermis.
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| Free Research Field |
皮膚科学
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