Development of Quantitative Cerebral Blood Flow and Oxygen Metabolism using O-17 Water and Oxygen Molecules

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293269
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: Kudo Kohsuke 北海道大学, 大学病院, 准教授 (10374232)
• Co-Investigator(Kenkyū-buntansha): 真鍋 治 北海道大学, 医学(系)研究科(研究院), 助教 (40443957) ; 真鍋 徳子 北海道大学, 大学病院, 講師 (70463742) ; 佐々木 真理 岩手医科大学, 医学部, 教授 (80205864) ; 加藤 扶美 北海道大学, 大学病院, 助教 (80399865) ; 藤間 憲幸 北海道大学, 大学病院, 助教 (80431360) ; 宮本 憲幸 北海道大学, 大学病院, 特任助教 (10707110)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 酸素代謝 / 脳血流 / MRI / O-17

Outline of Final Research Achievements

Signal simulations for the various tissue were conducted using theoretical equations of MRI signals. Good correlations were noted between signal simulation and O-17 phantom signal, and conversion method from MRI signal to O-17 concentration was determined. Based on the MRI scans of normal volunteers, scan method with FSE sequence was established, and development of algorithm for quantitative analysis of cerebral blood flow.
Manufacturing of O-17 oxygen was established, and inhalation apparatus of O-17 was designed. Smaller O-17 phantom was created, and MRI scans with animal MRI were performed. Good image contrast was obtained for marmosets with the administration of O-17 water.

Free Research Field

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