Application of cell cycle progression index to radiosensitivity evaluation and analysis of background factors on chromosome aberration

2017 Fiscal Year Final Research Report

• Project/Area Number: 26293270
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hirosaki University
• Principal Investigator: Miura Tomisato 弘前大学, 保健学研究科, 准教授 (20261456)
• Co-Investigator(Kenkyū-buntansha): 阿部 悠 福島県立医科大学, 医学部, 助教 (00722472) ; 葛西 宏介 弘前大学, 保健学研究科, 講師 (50400148) ; 吉田 光明 弘前大学, 被ばく医療総合研究所, 教授 (60182789) ; 坂井 晃 福島県立医科大学, 医学部, 教授 (70284221) ; 中田 章史 北海道薬科大学, 薬学部, 講師 (70415420)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 細胞遺伝学的線量評価 / 緊急被ばく医療 / 染色体異常 / 放射線感受性 / メタボリックシンドローム

Outline of Final Research Achievements

In this study, we investigated the clinical laboratory index on chromosome aberration and examined the usefulness of cell cycle progression index (CPI) as a radiosensitivity evaluation tool. Ankle brachial pressure index (ABI), one of the indexes related to atherosclerosis, was correlated with the frequency of dicentric chromosomes induced by 3 Gy X-ray irradiation and CPI . In addition, a positive correlation was found between CPI and blood glucose level.
It is suggested that radiation induced chromosomal abnormalities increase in patients with arteriosclerosis and that CPI may be useful as a method for evaluating radiation individual susceptibility.

Free Research Field

細胞遺伝学的線量評価