Radiation-induced injury in tissue-specific stem cells for evaluating non-cancer disease risks

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293279
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Nagasaki University
• Principal Investigator: LI Tao-Sheng 長崎大学, 原爆後障害医療研究所, 教授 (50379997)
• Co-Investigator(Kenkyū-buntansha): 工藤 崇 長崎大学, 原爆後障害医療研究所, 教授 (20330300) ; 浦田 芳重 長崎大学, 原爆後障害医療研究所, 助教 (30185087) ; 後藤 信治 長崎大学, 原爆後障害医療研究所, 助教 (50186889) ; 小野 悠介 長崎大学, 原爆後障害医療研究所, 助教 (60601119)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 幹細胞 / 放射線 / 非がん疾患リスク

Outline of Final Research Achievements

In this study, we experimentally investigated radiation-induced injuries of cardiac stem cells, which might indirectly indicate future cardiovascular disease risks.
We found that the whole body exposure of healthy adult mouse to 3 Gy gamma ray significantly reduced the number, decreased telomerase activity, and increased DNA damage of cardiac stem cells, and also significantly impaired the self-regenerative potency of heart after injury. According to our data, radiation-induced changes on the c-kit expression, telomerase activity, and DNA damage of cardiac stem cells may server as parameters for indirectly evaluating future cardiovascular disease risks.

Free Research Field

医歯薬学