The identification of novel microRNAs regulating cancer stem cell properties and the clinical application to therapeutic strategy in gastrointestinal cancer

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293290
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Kumamoto University
• Principal Investigator: BABA Hideo 熊本大学, 大学院生命科学研究部(医), 教授 (20240905)
• Co-Investigator(Kenkyū-buntansha): 石本 崇胤 熊本大学, 国際先端医学研究機構, 准教授 (00594889) ; 馬場 祥史 熊本大学, 大学院生命科学研究部(医), 講師 (20599708) ; 岩槻 政晃 熊本大学, 大学院生命科学研究部(医), 助教 (50452777) ; 今村 裕 公益財団法人がん研究会, その他部局等, 医員 (70583045) ; 渡邊 雅之 公益財団法人がん研究会, その他部局等, 食道担当部長 (80254639)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 癌幹細胞 / microRNA / 腫瘍微小環境

Outline of Final Research Achievements

Increasing evidence has shown that tumor heterogeneity is a result of the hierarchical organization of cancer stem cells (CSCs), which are strongly associated with tumor relapse and metastasis. Our recent studies have revealed that particular microRNAs are deeply implicated in CSC properties in various types of gastrointestinal cancer. Moreover, we demonstrated that tumor-associated-macrophages and cancer-associated-fibroblasts in tumor microenvironment affect the expression of these microRNAs and promote cancer progression.

Free Research Field

外科学、腫瘍生物学