Elucidation of non-invasive biomarker for early dtection of colorectal cancer

2018 Fiscal Year Final Research Report

• Project/Area Number: 26293301
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Mie University
• Principal Investigator: Kusunoki Masato 三重大学, 医学系研究科, 教授 (50192026)
• Co-Investigator(Kenkyū-buntansha): 問山 裕二 三重大学, 医学部附属病院, 准教授 (00422824) ; 井上 靖浩 三重大学, 医学系研究科, 客員准教授 (20324535) ; 毛利 靖彦 三重大学, 医学系研究科, 客員准教授 (70345974) ; 沖上 正人 三重大学, 医学系研究科, リサーチアソシエイト (90722596)
• Project Period (FY): 2014-04-01 – 2019-03-31
• Keywords: 大腸癌 / 早期診断 / バイオマーカー

Outline of Final Research Achievements

The aim of this study was to identify non-invasive diagnostic biomarker for colorectal cancer. Array-based comprehensive analysis demonstrated that miR-1290 was one of candidate for diagnostic marker in CRC patients, and we validated diagnostic potential of serum miR-1290 using serum specimens from patients with adenoma and CRC. Surprisingly, serum miR-1290 could identify patients with adenoma or CRC with high accuracy (AUC=0.83, 0.718, respectively).

Free Research Field

消化器外科学

Academic Significance and Societal Importance of the Research Achievements

本研究結果を用いることで、大腸癌ならびにその前駆病変を早期に診断・同定しうる可能性が考慮された。