CONQUEST OF THE SCIRRHOUS GASTRIC CANCER: AUTOPHAGY OF CANCER STEM CELLS AND DEVELOPMENT OF MOLECULAR TARGET

2017 Fiscal Year Final Research Report

• Project/Area Number: 26293307
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Osaka City University
• Principal Investigator: Hirakawa Kosei 大阪市立大学, 大学院医学研究科, 医学部附属病院長 (40188652)
• Co-Investigator(Kenkyū-buntansha): 八代 正和 大阪市立大学, 大学院医学研究科, 准教授 (60305638)
• Research Collaborator: 福岡 達成 , 大学院生 ; 森崎 珠実 , 大学院生 ; 木下 春人 , 大学院生 ; 増田 剛 , 大学院生 ; 笠島 裕明 , 大学院生
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: スキルス胃癌 / 難治癌 / オートファジー / 癌幹細胞 / クロロキン

Outline of Final Research Achievements

Scirrhous gastric cancer is a refractory cancer. The aim of this study was to elucidate the intractable mechanisms of the scirrhous gastric cancer intractable from the viewpoint of autophagy of cancer stem cells. The expression of LC3A and LC3B was high in cancer stem cells of scirrhous gastric cancer. Autophagy was induced by oxidative stress. The proliferation of cancer stem cells was significantly inhibited by chloroquine. The expression of p62, LC-3, beclin-1 of the gastric cancer tissue was correlated with skills and metastasis. These findings suggested that autophagy was associated with the cancer stem cells of scirrhous gastric cancer, and suggested that autophagy inhibitor, chloroquine, might be useful for the inhibition of cancer stem cells.

Free Research Field

腫瘍外科