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2017 Fiscal Year Final Research Report

CONQUEST OF THE SCIRRHOUS GASTRIC CANCER: AUTOPHAGY OF CANCER STEM CELLS AND DEVELOPMENT OF MOLECULAR TARGET

Research Project

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Project/Area Number 26293307
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionOsaka City University

Principal Investigator

Hirakawa Kosei  大阪市立大学, 大学院医学研究科, 医学部附属病院長 (40188652)

Co-Investigator(Kenkyū-buntansha) 八代 正和  大阪市立大学, 大学院医学研究科, 准教授 (60305638)
Research Collaborator 福岡 達成  , 大学院生
森崎 珠実  , 大学院生
木下 春人  , 大学院生
増田 剛  , 大学院生
笠島 裕明  , 大学院生
Project Period (FY) 2014-04-01 – 2018-03-31
Keywordsスキルス胃癌 / 難治癌 / オートファジー / 癌幹細胞 / クロロキン
Outline of Final Research Achievements

Scirrhous gastric cancer is a refractory cancer. The aim of this study was to elucidate the intractable mechanisms of the scirrhous gastric cancer intractable from the viewpoint of autophagy of cancer stem cells. The expression of LC3A and LC3B was high in cancer stem cells of scirrhous gastric cancer. Autophagy was induced by oxidative stress. The proliferation of cancer stem cells was significantly inhibited by chloroquine. The expression of p62, LC-3, beclin-1 of the gastric cancer tissue was correlated with skills and metastasis. These findings suggested that autophagy was associated with the cancer stem cells of scirrhous gastric cancer, and suggested that autophagy inhibitor, chloroquine, might be useful for the inhibition of cancer stem cells.

Free Research Field

腫瘍外科

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Published: 2019-03-29  

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