Regenerative therapy for postoperative paraplegia after thoracic aortic surgery using bone marrow stem cell cultured in microgravity

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293312
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular surgery
• Research Institution: Hiroshima University
• Principal Investigator: Sueda Taijiro 広島大学, 医歯薬保健学研究院(医), 教授 (10162835)
• Co-Investigator(Kenkyū-buntansha): 弓削 類 広島大学, 医歯薬保健学研究院(保), 教授 (20263676)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 胸腹部大動脈瘤 / 対麻痺 / 脊髄再生 / 骨髄間葉系幹細胞 / 微小重力培養 / 神経分化誘導 / 神経幹細胞

Outline of Final Research Achievements

Paraplegia is devastating complication after thoracoabdominal aortic surgery. Bone marrow stem cell was cultivated using the microgravited (10-3G) culture device (Gravite). Bone marrow stem cell can be cultivated under undifferentiated condition by microgravitated clture device. Rat paraplegia model was made using simple balloon occlusion of descending aorta for 30min. Control group (serine), simple cultivated bone marrow stem cells and microgravitated bone marrow stem cells were injected into rat paraplegia model via tail vein. Bone marrow degeneration can be treated by injection of cultivated bone marrow stem cells.

Free Research Field

心臓大血管外科