Research for improvement of local CNS drug delivery system and its generalization

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293319
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Tohoku University
• Principal Investigator: Saito Ryuta 東北大学, 大学病院, 助教 (10400243)
• Co-Investigator(Kenkyū-buntansha): 冨永 悌二 東北大学, 医学(系)研究科(研究院), 教授 (00217548) ; 芳賀 洋一 東北大学, その他の研究科, 教授 (00282096) ; 荒井 啓行 東北大学, 加齢医学研究所, 教授 (30261613)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 薬剤送達 / 中枢神経系 / 脳腫瘍 / アルツハイマー病 / てんかん

Outline of Final Research Achievements

Recently, we have been working towards CNS (central nervous system) drug delivery system that enables effective distribution of the infusate. Aiming at improved and stable drug delivery system, we developed ultrasound facilitated drug delivery (UFD) device that achieve improved distribution in brain parenchyma. In this study, in order to improve the system, we developed pressure-controlled microinfusion pump. We demonstrated that our system enabled constant pressure delivery within +/- 1mmHg pressure range. Second generation UFD device was also fabricated for stable delivery. Subsequently, to prove that our device is applicable to multiple CNS diseases, we attempted to deliver therapeutic agents to epilepsy model, spinal disease model, and Alzheimer disease model. Anti-epileptic agents worked in epilepsy model, chemotherapeutic drug worked in spinal tumor model. Both of these headed for publication of the literature.

Free Research Field

脳神経外科学