2016 Fiscal Year Final Research Report
Development of chondrocyte differentiation method from human iPS cells
| Project/Area Number |
26293330
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SAITO Taku 東京大学, 医学部附属病院, 講師 (30456107)
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| Co-Investigator(Kenkyū-buntansha) |
門野 夕峰 東京大学, 医学部附属病院, 准教授 (70401065)
矢野 文子 東京大学, 医学部附属病院, 助教 (80529040)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 整形外科学 / 変形性関節症 / 再生医療学 |
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| Outline of Final Research Achievements |
iPS cell is attractive cell source for regenerative medicine. The present study has established a novel chondrocyte induction protocol from human iPS cells by only two chemical compounds within one week. We did not find any undifferentiated cells after one week culture by the protocol, indicating the markedly high efficiency. When we implanted the differentiated cells into mouse knee joints, hyaline cartilage formation was observed.
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| Free Research Field |
整形外科学
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