Involvement of nociceptive afferents in cancer growth and pain

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293344
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Wakayama Medical University
• Principal Investigator: Kawamata Tomoyuki 和歌山県立医科大学, 医学部, 教授 (80336388)
• Co-Investigator(Kenkyū-buntansha): 鈴木 雅美 国立研究開発法人国立がん研究センター, その他部局等, 研究員 (80434182) ; 栗山 俊之 和歌山県立医科大学, 医学部, 講師 (10405467) ; 谷奥 匡 和歌山県立医科大学, 医学部, 学内助教 (50554656)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 疼痛 / がん / 末梢神経

Outline of Final Research Achievements

The purpose of this study was to clarify the involvement of nociceptive afferents in tumor growth. Deletion of peripheral afferents or deletion of CGRP gene inhibited tumor growth. Deletion of TRPV1, which is highly expressed in the CGRP-positive afferents, did not affect tumor growth. Next, involvement of primary afferents with distinct neurochemical feature was examined using some neurotoxins including IB4-saporin and CTB-saporin. Neither B4-binding nor myelinated afferents were involved in tumor growth. Our study showed that IB4-negative and CGRP-positive unmyelinated afferents facilitated tumor growth.

Free Research Field

麻酔科学