2017 Fiscal Year Final Research Report
Clarification of the tumor microenvironment in the development of urothelial carcinoma using animal model
| Project/Area Number |
26293349
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
宮崎 淳 国際医療福祉大学, 医学部, 主任教授 (10550246)
小島 崇宏 筑波大学, 医学医療系, 講師 (40626892)
常樂 晃 筑波大学, 医学医療系, 講師 (60436277)
河合 弘二 筑波大学, 医学医療系, 講師 (90272195)
高岡 栄一郎 筑波大学, 医学医療系, 講師 (50625340)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | モルモット膀胱癌 / 脂質免疫 / ミコール酸 / Mycobacterium bovis BCG / CD1b |
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| Outline of Final Research Achievements |
We tested that guinea pigs can have bladder cancer by orally ingesting bracken. As a result of HE staining and immunostaining of the tumor of the bladder in the guinea pigs, it was confirmed that the tumor were non-muscle invaseve bladdere tumora. Guinea pigs have the same CD1b as human for lipid immunity. CD1b is a receptor for mycolic acid and we believe that future use of this bladder cancer cell line will elucidate the involvement of lipid immunity and T cell immunity.
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| Free Research Field |
尿路上皮癌
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