Development of novel nucleic acid treatment through nano-micelles delivering tumor suppressive microRNA in bladder cancer

2016 Fiscal Year Final Research Report

• Project/Area Number: 26293354
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Kagoshima University
• Principal Investigator: ENOKIDA Hideki 鹿児島大学, 医歯学域医学系, 准教授 (80347103)
• Co-Investigator(Kenkyū-buntansha): 関 直彦 千葉大学, 大学院医学研究院, 准教授 (50345013) ; 中川 昌之 鹿児島大学, 医歯学域医学系, 教授 (90164144) ; 千代丸 剛 鹿児島大学, 医学部・歯学部附属病院, 助教 (60593796)
• Co-Investigator(Renkei-kenkyūsha): KATAOKA Kazunori 東京大学, 疾患生命工学センター, 教授 (00130245) ; MIYATA Kanjiro 東京大学, 疾患生命工学センター, 准教授 (50436523)
• Research Collaborator: INOGUCHI Satoru 鹿児島大学, 医歯学総合研究科, 大学院生 ; ISHIHARA Tomoaki 鹿児島大学, 医歯学総合研究科, 大学院生
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: マイクロRNA / 膀胱癌 / ナノミセル

Outline of Final Research Achievements

Based on the microRNAs expression profile by next generation sequencing in bladder cancer, we identified several tumor suppressive microRNAs including miR-23b/24/27b, miR-144-5p/3p, miR-26a/b-5, and miR-199 family and found their target tumor-associated genes. Next, we established nano-micelles carrier containing tumor suppressive miR-218 and administrated it intravenously to xenograft model mice. Finally, we confirmed that the red-pigmented carrier was successfully delivered to cancer tissues.

Free Research Field

マイクロRNA